Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | SU-16f, PDGFR Tyrosine Kinase Inhibitor VII | ||||||||||||||||||||||||
| Chemical Name | (E)-3-(2,4-dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid | ||||||||||||||||||||||||
| Application | SU 16f is a potent PDGFRβ inhibitor | ||||||||||||||||||||||||
| CAS Number | 251356-45-3 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 386.44 | ||||||||||||||||||||||||
| Molecular Formula | C₂₄H₂₂N₂O₃ | ||||||||||||||||||||||||
| SMILES | O=C(O)CCC1=C(C)NC(/C=C2C(NC3=C\2C=CC(C4=CC=CC=C4)=C3)=O)=C1C | ||||||||||||||||||||||||
| Target & IC50 | Flk-1: IC50 = 0.14 μM FGFR1: IC50 = 2.29 μM PDGFRβ: IC50 = 10 nM |
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| Shipping | Room Temperature | ||||||||||||||||||||||||
| Storage | Room Temperature | ||||||||||||||||||||||||
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| Solubility | |
| Soluble in DMSO (100 mM) |
| Product Description | |
SU 16f is a selective PDGFRβ inhibitor with an IC50=10nM. In vitro studies demonstrate that SU 16f also inhibits HUVEC and NIH3T3 cell proliferation with an IC50=0.11μM. In addition, SU 16f displays 14 fold selectivity towards PDGFRβ compared to Flk-1 (VEGFR2), 229-fold over Flg (FGFR1) and 10000-fold over EGFR. SU 16f is an inhibitor of Flk-1. |
