Protein Inhibitors - EHNA hydrochloride (CAS: 51350-19-7)

EHNA hydrochloride (CAS: 51350-19-7)

Catalog #：EBC51094

Biological Activity

Synonyms

NSC263164, EHNA HCl

Chemical Name

(2R,3S)-3-(6-Aminopurin-9-yl)nonan-2-ol hydrochloride

Application

EHNA hydrochloride is a potent adenosine deaminase and phosphodiesterase type 2 inhibitor

CAS Number

58337-38-5

Purity

≥98%

Molecular Weight

313.8

Molecular Formula

C₁₄H₂₃N₅O·HCl

SMILES

CCCCCC[C@@H]([C@@H](C)O)N1C=NC2=C1N=CN=C2N.Cl

Target & IC50

PDE II: IC50 = 0.8 μM
PDE I/II/IV isozymes: IC50 ≥100 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.1864 ml	15.9322 ml	31.8644 ml
5 mM	0.6373 ml	3.1864 ml	6.3729 ml
10 mM	0.3186 ml	1.5932 ml	3.1864 ml
50 mM	0.0637 ml	0.3186 ml	0.6373 ml

Solubility
DMSO : 100 mg/mL (318.64 mM)

Product Description

EHNA acts as an inhibitor of adenosine deaminase (ADA) and as a selective inhibitor of cyclic nucleotide phosphodiesterase- 2 (PDE2). EHNA has been used to investigate the protective response of adenosine in myocardial cell studies in vitro, and to understand the role that the adenosine pathway plays in heart studies. Urinary bladder studies in vitro show that EHNA blocks the ATPase and motor activities of cytoplasmic dynein in vitro and cardiac myocyte studies show EHNA to block the activity of cGMP-stimulated phosphodiesterase.