Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | MK-2206 2HCl, MK2206 | ||||||||||||||||||||||||
| Chemical Name | 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one;dihydrochloride | ||||||||||||||||||||||||
| Application | MK-2206 dihydrochloride is a highly selective pan-Akt inhibitor activated by the pleckstrin homology domain | ||||||||||||||||||||||||
| CAS Number | 1032350-13-2 | ||||||||||||||||||||||||
| Purity | ≥99.5% | ||||||||||||||||||||||||
| Molecular Weight | 480.39 | ||||||||||||||||||||||||
| Molecular Formula | C₂₅H₂₁N₅O•2HCl | ||||||||||||||||||||||||
| SMILES | C1CC(C1)(C2=CC=C(C=C2)C3=C(C=C4C(=N3)C=CN5C4=NNC5=O)C6=CC=CC=C6)N.Cl.Cl | ||||||||||||||||||||||||
| Target & IC50 | Akt1: IC50 = 8 nM Akt2: IC50 = 12 nM Akt3: IC50 = 65 nM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 12.5 mg/mL (26.02 mM) H₂O: 1 mg/mL (2.08 mM) |
| Product Description | |
MK-2206 is a highly allosteric selective Akt1,2,3 (IC50 5nM, 12nM, 65nM) inhibitor. It is reported to inhibit the proliferation of cancer cell lines when used synergistically with cytotoxic agents such as erlotinib or lapatinib and significantly enhances cell apoptosis. |
