| Biological Activity | |||||||||||||||||||||||||
| Synonyms | 11-Deoxojervine, Hh signaling inhibitor | ||||||||||||||||||||||||
| Chemical Name | (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a, 4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro- 3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'( 3'H)-furo[3,2-b]pyridin]-3-ol | ||||||||||||||||||||||||
| Application | Cyclopamine is a hedgehog signaling pathway and Smo inhibitor | ||||||||||||||||||||||||
| CAS Number | 4449-51-8 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 411.63 | ||||||||||||||||||||||||
| Molecular Formula | C₂₇H₄₁NO₂ | ||||||||||||||||||||||||
| SMILES | CC1CC2C(C(C3(O2)CCC4C5CC=C6CC(CCC6(C5CC4=C3C)C)O)C)NC1 | ||||||||||||||||||||||||
| Target & IC50 | Smoothened: IC50 = 46 nM | ||||||||||||||||||||||||
| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| Ethanol : 41 mg/mL (99.61 mM) |
| Product Description | |
Cyclopamine is a steroidal alkaloid inhibitor of the hedgehog signaling pathway (Hh), an essential pathway for embryonic development. It is reported to be capable of inducing differentiation of stem cells into endocrine cells and various anti-cancer applications by suppressing excess Hh activity. |
