Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | GSK-3 Inhibitor XVI | ||||||||||||||||||||||||
| Chemical Name | 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile | ||||||||||||||||||||||||
| Application | CHIR-99021 is a GSK-3α/β inhibitor | ||||||||||||||||||||||||
| CAS Number | 252917-06-9 | ||||||||||||||||||||||||
| Purity | ≥99.0% | ||||||||||||||||||||||||
| Molecular Weight | 465.34 | ||||||||||||||||||||||||
| Molecular Formula | C₂₂H₁₈Cl₂N₈ | ||||||||||||||||||||||||
| SMILES | N#CC(C=N1)=CC=C1NCCNC2=NC=C(C3=NC(C)=CN3)C(C4=CC=C(Cl)C=C4Cl)=N2 | ||||||||||||||||||||||||
| Target & IC50 | GSK-3α: IC50 = 10 nM GSK-3β: IC50 = 6.7 nM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 78 mg/mL (167.62 mM) |
| Product Description | |
CHIR 99021 is an aminopyrimidine derivate that is a selective and potent inhibitor of glycogen synthase kinase 3 (GSK-3). It is used to maintain human and mouse stem cell lines and, in combination with other reagents, to chemically reprogram somatic cells into stem cells. |
