| Biological Activity |
| Synonyms |
CHIR 98014, CHIR-98014, CT98014 |
| Chemical Name |
N6-[2-[[4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)-2-pyrimidinyl]amino]ethyl]-3-nitro-2,6-Pyridinediamine |
| Application |
CHIR-98014 is a selective and ATP-competitive inhibitor of GSK-3β |
| CAS Number |
252935-94-7 |
| Purity |
≥99.0% |
| Molecular Weight |
486.31 |
| Molecular Formula |
C₂₀H₁₇Cl₂N₉O₂ |
| SMILES |
C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N |
| Target & IC50 |
GSK-3 β: IC50 = 0.58 nM
GSK-3 α: IC50 = 0.65 nM |
| Shipping |
Gel Pack |
| Storage |
Store at -20°C |
| Preparing Stock Solutions |
Molecular Structure |
| ConcentrationSolventMass |
1 mg |
5 mg |
10 mg |
| 1 mM |
2.0563 ml |
10.2815 ml |
20.5630 ml |
| 5 mM |
0.4113 ml |
2.0563 ml |
4.1126 ml |
| 10 mM |
0.2056 ml |
1.0282 ml |
2.0563 ml |
| 50 mM |
0.0411 ml |
0.2056 ml |
0.4113 ml |
|
|
|
