Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | Ascotoxin, Cyanein, Decumbin, Synergisidin | ||||||||||||||||||||||||
| Chemical Name | (1R,2E,6S,10E,11aS,13S,14aR)-1,13-Dihydroxy-6-methyl-1,6,7,8,9,11a,12,13,14,14a-decahydro-4H-cyclopenta[f]oxacyclotridecin-4-one | ||||||||||||||||||||||||
| Application | Brefeldin A (BFA) is a lactone antibiotic and a specific inhibitor of protein trafficking | ||||||||||||||||||||||||
| CAS Number | 20350-15-6 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 280.36 | ||||||||||||||||||||||||
| Molecular Formula | C₁₆H₂₄O₄ | ||||||||||||||||||||||||
| SMILES | O[C@@H]1C[C@H]2[C@H](O)C=CC(=O)O[C@@H](C)CCCC=C[C@@H]2C1 | ||||||||||||||||||||||||
| Target & IC50 | B-cell specific antigen receptor-induced NF-kB activation: IC50 = 420 nM | ||||||||||||||||||||||||
| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 14 mg/mL (50 mM)
Ethanol: 2.8 mg/mL (10 mM) |
| Product Description | |
Brefeldin A is a lactone antibiotic originating discovered in fungi capable of inhibiting protein transport from the endolasmic reticulum to the Golgi apparatus. It is reported to act on the guanine nucleotide exchange factor named GBF1 that mediates the formation of transport vesicles and the unfolded protein response can result in apoptosis in some cells. |
