Protein Inhibitors - Z-FA-FMK (CAS: 197855-65-5)

Z-FA-FMK (CAS: 197855-65-5)

Catalog #：EBC51065

Biological Activity

Synonyms

Cathepsin B inhibitor

Application

Z-FA-FMK is inhibits effector, but not initator caspases in vitro, and suppress some forms of apoptosis

CAS Number

197855-65-5

Purity

≥98.0%

Molecular Weight

386.42

Molecular Formula

C₂₁H₂₃FN₂O₄

SMILES

CC(C(=O)CF)NC(=O)C(CC1=CC=CC=C1)NC(=O)OCC2=CC=CC=C2

Target & IC50

Cysteine protease

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.5879 ml	12.9393 ml	25.8786 ml
5 mM	0.5176 ml	2.5879 ml	5.1757 ml
10 mM	0.2588 ml	1.2939 ml	2.5879 ml
50 mM	0.0518 ml	0.2588 ml	0.5176 ml

Solubility
DMSO: 77 mg/mL (199.27 mM) Ethanol: 48 mg/mL (124.22 mM)

Product Description

Z-FA-FMK is an irreversible inhibitor of cysteine proteases, such as cathepsin B, L, and S, that do not require a P1 Asp residue. The compound has also inhibitited papain and cruzain. Z-FA-FMK has been shown to selectively inhibit effector caspase-2, caspase-3, caspase-6, and caspase-7 without affecting initiator caspase-8 and caspase-10 while showing minimal toxicity to normal mammalian cells in vitro. Due to Z-FA-FMK's effector caspase specificity, the compound has been recorded to inhibit some forms of caspase mediated apoptosis. The compound has been observed to be an effective in time dependent inactivation of cathepsin B isozymes from a number of tissues. Studies show Cathepsin B-like activity plays a role in the cascade of proteolytic cartilage destruction. Z-FA-FMK is an inhibitor of cathepsin H.