Protein Inhibitors - Doxorubicin hydrochloride (CAS: 25316-40-9)

Doxorubicin hydrochloride (CAS: 25316-40-9)

Catalog #：EBC51063

Biological Activity

Synonyms

NSC 123127, DOX, Hydroxydaunorubicin HCl, Topoisomerase II inhibitor

Chemical Name

(7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione;hydrochloride

Application

Doxorubicin hydrochloride is an anthracycline antitumor antibiotic topoisomerase II inhibitor, DNA intercalator and powerful cytotoxic agent

CAS Number

25316-40-9

Purity

≥99.0%

Molecular Weight

579.98

Molecular Formula

C₂₇H₃₀ClNO₁₁

SMILES

C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C(C4=C(C(=C23)O)C(=O)C5=C(C4=O)C=CC=C5OC)O)(C(=O)CO)O)N)O.Cl

Target & IC50

Topoisomerase I : IC50 = 0.8 μM
Topoisomerase II : IC50 = 2.67 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.7242 ml	8.6210 ml	17.2420 ml
5 mM	0.3448 ml	1.7242 ml	3.4484 ml
10 mM	0.1724 ml	0.8621 ml	1.7242 ml
50 mM	0.0345 ml	0.1724 ml	0.3448 ml

Solubility
DMSO : 35.71 mg/mL (61.57 mM) H2O : 20 mg/mL (34.48 mM)

Product Description

Doxorubicin hydrochloride is a DNA intercalator and powerful cytotoxic agent. Once Doxorubicin hydrochloride associates with the DNA groove, a covalent linkage forms between a DNA base and the pendant sugar of the small molecule. The intercalation into DNA blocks the replication of DNA by blocking Topo II (Topoisomerase II). This general mechanism gives Doxorubicin hydrochloride efficacy in a wide range of different cell types. Additionally, the expression of the oncogenes c-Myc and c-Jun is also down regulated by the chemical and a significant correlation was reported between the level of expression of these genes and the degree of cell growth inhibition conferred by Doxorubicin hydrochloride. Doxorubicin hydrochloride is an inhibitor of AMPK, TERT and POLR. Doxorubicin hydrochloride is also known as Hydroxydaunorubicin Hydrochloride, DOX, and (8S,10S)-10-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione, monohydrochloride.