Other Biochemicals - FCCP (CAS: 370-86-5)

FCCP (CAS: 370-86-5)

Catalog #：EBC51061

Biological Activity

Synonyms

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, Trifluoromethoxy carbonylcyanide phenylhydrazone

Chemical Name

Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone

Application

FCCP is a very potent oxidative phosphorylation uncoupler found in mitochondria

CAS Number

370-86-5

Purity

≥99.0%

Molecular Weight

254.17

Molecular Formula

C₁₀H₅F₃N₄O

SMILES

FC(F)(F)Oc1ccc(cc1)NN=C(/C#N)C#N

Target & IC50

hypoxia-induced HIF1 activation: IC50 = 510 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.9344 ml	19.6719 ml	39.3437 ml
5 mM	0.7869 ml	3.9344 ml	7.8687 ml
10 mM	0.3934 ml	1.9672 ml	3.9344 ml
50 mM	0.0787 ml	0.3934 ml	0.7869 ml

Solubility
DMSO: 50 mg/mL (196.72 mM) Ethanol: 50 mg/mL (196.72 mM)

Product Description

FCCP is an oxidative phosphorylation uncoupler in mitochondria. FCCP is capable of depolarizing plasma and mitochondrial membranes. FCCP disrupts ATP synthesis by transporting protons across cell membranes. FCCP induces complete depolymerization of microtubules at 40 µM by increasing intracellular pH via the disruption of the mitochondrial H+ gradient and by decreasing the stability of microtubules by impairing the binding of microtubule-associated proteins. FCCP is also known as Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone, and 2-[2-[4-(trifluoromethoxy)phenyl]hydrazinylidene]-propanedinitrile.