Protein Inhibitors - 3-methyladenine (CAS: 5142-23-4)

3-methyladenine (CAS: 5142-23-4)

Catalog #：EBC51054

Biological Activity

Synonyms

3-MA, NSC 66389

Chemical Name

3-Methyl-3H-purin-6-amine

Application

3-methyladenine is a multi-use inhibitor that inhibits autophagy by blocking autophagosome formation via the inhibition of type III Phosphatidy

CAS Number

5142-23-4

Purity

≥99.0%

Molecular Weight

149.15

Molecular Formula

C₆H₇N₅

SMILES

NC1=C2N=CN=C2N(C)C=N1

Target & IC50

Class III PI3K: IC50 = 4.5 mM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	6.7047 ml	33.5233 ml	67.0466 ml
5 mM	1.3409 ml	6.7047 ml	13.4093 ml
10 mM	0.6705 ml	3.3523 ml	6.7047 ml
50 mM	0.1341 ml	0.6705 ml	1.3409 ml

Solubility
DMSO: 3 mg/mL (20.11 mM), warmed Ethanol: 4 mg/mL (26.81 mM) H20: 3 mg/mL (20.11 mM) warmed

Product Description

3-methyladenine is a synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation. Autophagy Inhibitor, 3-MA is a PI 3-kinase p100 (class III PI 3-kinase inhibitor) that displays distinctly different properties from the PI 3-kinase inhibitors LY 294002 and Wortmannin, in that treatment of cells with 3-MA results in specific redistribution of mannose 6-phosphate/insulin-like growth factor II receptor (MPR300), but does not cause the enlargement of late endosomal/lysosomal compartments. Autophagy Inhibitor, 3-MA is also an inhibitor of PI 3-kinase p110 γ.