Protein Inhibitors - 3-Deazaneplanocin A (CAS: 102052-95-9)

3-Deazaneplanocin A (CAS: 102052-95-9)

Catalog #：EBC51051

Biological Activity

Synonyms

DZNep, NSC 617989

Chemical Name

(1S,2R,5R)-5-(4-Aminoimidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol

Application

3-Deazaneplanocin A is an epigenetic modifier, inhibiting histone h3 lysine 27

CAS Number

102052-95-9

Purity

≥98.0%

Molecular Weight

262.3

Molecular Formula

C₁₂H₁₄N₄O₃

SMILES

O[C@@H]1[C@H](O)C(CO)=C[C@H]1N2C=NC3=C2C=CN=C3N

Target & IC50

EZH2

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.8129 ml	19.0643 ml	38.1286 ml
5 mM	0.7626 ml	3.8129 ml	7.6257 ml
10 mM	0.3813 ml	1.9064 ml	3.8129 ml
50 mM	0.0763 ml	0.3813 ml	0.7626 ml

Solubility
DMSO: 20 mg/ml DMF: 30 mg/ml

Product Description

3-Deazaneplanocin is a highly potent inhibitor of S-adenosylhomocysteine hydrolase with Ki value of 0.05 nM. 3-Deazaneplanocin A is an epigenetic modifier, inhibiting histone h3 lysine 27. The mechanism for this action is the inhibition of lysine methyltransferases, especially EZH2. It is reported to induce apoptosis in cancer cells to the exclusion of normal cells and useful in the generation of chemically induced pluripotent stem cells (CiPSCs).