(Z)-4-Hydroxytamoxifen (CAS: 68047-06-3)
Catalog #:EBC51048
Biological Activity
Synonyms 4-Hydroxytamoxifen, trans-4-Hydroxytamoxifen
Chemical Name 4-[(Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol
Application (Z)-4-Hydroxytamoxifen is an active metabolite of the antineoplastic agent Tamoxifen and an anti-estrogen agent
CAS Number 68047-06-3
Purity ≥99.0%
Molecular Weight 387.51
Molecular Formula C₂₆H₂₉NO₂
SMILES CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=C(O)C=C3.[(Z)]
Target & IC50 MCF7 : IC50 = 0.5 nM (human)
Estrogen receptor beta: IC50 = 0.5 nM (human)
Shipping Gel Pack
Storage Store at -20°C
Preparing Stock Solutions Molecular Structure
ConcentrationSolventMass 1 mg 5 mg 10 mg
1 mM 2.5806 ml 12.9028 ml 25.8055 ml
5 mM 0.5161 ml 2.5806 ml 5.1611 ml
10 mM 0.2581 ml 1.2903 ml 2.5806 ml
50 mM 0.0516 ml 0.2581 ml 0.5161 ml
Solubility
DMSO: 28 mg/mL (72.26 mM)
Product Description

(Z)-4-Hydroxytamoxifen is a Tamoxifen metabolite with increased potency and a 100x higher affinity for the estrogen receptors. It is also reported to inhibit lipid peroxidation and can be used to activate intein-linked or estrogen receptor ERT2 domain fused Cas9 to reduce off target effects in CRISPR-mediated gene editing.

For Research Use Only, Not For Diagnostic Or Therapeutic Procedures.
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