Protein Inhibitors - AG 126 (CAS: 118409-62-4)

AG 126 (CAS: 118409-62-4)

Catalog #：EBC51047

Biological Activity

Synonyms

Tyrphostin AG126

Chemical Name

2-[(3-Hydroxy-4-nitrophenyl)methylidene]propanedinitrile

Application

AG 126 is selectively inhibits phosphorylation of ERK 1 and ERK 2

CAS Number

118409-62-4

Purity

≥98.70%

Molecular Weight

215.17

Molecular Formula

C₁₀H₅N₃O₃

SMILES

C1=CC(=C(C=C1C=C(C#N)C#N)O)[N+](=O)[O-]

Target & IC50

epidermal GFRK: IC50 = 450 M

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.6475 ml	23.2374 ml	46.4749 ml
5 mM	0.9295 ml	4.6475 ml	9.2950 ml
10 mM	0.4648 ml	2.3237 ml	4.6475 ml
50 mM	0.0930 ml	0.4647 ml	0.9295 ml

Solubility
DMSO: 43 mg/mL (199.85 mM) Ethanol: 2 mg/mL (9.30 mM)

Product Description

AG 126 selectively inhibits the phosphorylation of ERK1 and ERK2 at 25-50 μM. It also acts as a cell-permeable inhibitor of lipopolysaccharide (LPS)-induced synthesis of tumor necrosis factor-α (TNF α) and nitric oxide in murine peritoneal macrophages. AG 126 blocks LPS-induced tyrosine phosphorylation of a p42MAPK/ERK2 protein substrate, as well as glucocorticoid-induced COX-2 activity in cells (IC₅₀ = 15.38 μM).