Protein Inhibitors - BAY 11-7082 (CAS: 19542-67-7)

BAY 11-7082 (CAS: 19542-67-7)

Catalog #：EBC51044

Biological Activity

Synonyms

BAY 11-7821

Chemical Name

(E)-3-(4-methylphenyl)sulfonylprop-2-enenitrile

Application

BAY 11-7082 is an anti-inflammatory agent and NFκB inhibitor

CAS Number

19542-67-7

Purity

≥99.0%

Molecular Weight

207.25

Molecular Formula

C₁₀H₉NO₂S

SMILES

N#C/C=C/S(=O)(C1=CC=C(C)C=C1)=O

Target & IC50

USP7: IC50 = 0.19 μM
NF-kappa-B p65 subunit nuclear translocation: IC50 = 3 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.8251 ml	24.1255 ml	48.2509 ml
5 mM	0.9650 ml	4.8251 ml	9.6502 ml
10 mM	0.4825 ml	2.4126 ml	4.8251 ml
50 mM	0.0965 ml	0.4825 ml	0.9650 ml

Solubility
DMSO: 20.7 mg/mL (100 mM) Ethanol: 5.2 mg/mL (25 mM)

Product Description

BAY 11-7082, a potential anti-inflammatory agent, is an irreversible inhibitor of IKK α and phosphorylation of cytokine-inducible IκBα (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-α, NFKBIA; IC₅₀=10 μM). In intact HUVECs, it inhibits TNFα-induced phosphorylation and degradation of IκBa (NFKBIA) without affecting constitutive phosphorylation. Inhibition of ιBα phosphorylation and degradation results in the inactivation of NFκB and thereby inhibits the expression of endothelial-leukocyte adhesion molecules: E-selectin, VCAM-1 and ICAM-11. BAY 11-7082 has also demonstrated stimulation of the stress-activated protein kinases, p38 and JNK-1.