Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | CI-1040, CI 1040, CI1040, PD 184352, PD-184352 | ||||||||||||||||||||||||
| Chemical Name | 2-(2-chloro-4-iodoanilino)-N-(cyclopropylmethoxy)-3,4-difluorobenzamide | ||||||||||||||||||||||||
| Application | PD184352 is a MEK inhibitor | ||||||||||||||||||||||||
| CAS Number | 212631-79-3 | ||||||||||||||||||||||||
| Purity | ≥99.0% | ||||||||||||||||||||||||
| Molecular Weight | 478.66 | ||||||||||||||||||||||||
| Molecular Formula | C₁₇H₁₄ClF₂IN₂O₂ | ||||||||||||||||||||||||
| SMILES | O=C(C1=CC=C(C(F)=C1NC2=CC=C(I)C=C2Cl)F)NOCC3CC3 | ||||||||||||||||||||||||
| Target & IC50 | MEK-1: IC50 = 2 nM Raf-1: IC50 = 12 nM MEK1/2: IC50 = 16 nM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 47.9 mg/mL (100 mM)
Ethanol: 12 mg/mL (25 mM) |
| Product Description | |
PD184352 is a MEK inhibitor (IC50 = 10-100 nM), a kinase upstream in the mitogen-activated protein kinase pathway (MAPK). Inhibition of MEK leads to a reduction of MAPK activation, suppressing colon tumor proliferation in mice with limited organism toxicity. PD 184,352 is an inhibitor of MEK-1 and MEK-2. |
