Protein Inhibitors - Veliparib (CAS: 912444-00-9)

Veliparib (CAS: 912444-00-9)

Catalog #：EBC51042

Biological Activity

Synonyms

ABT-888, NSC 737664

Chemical Name

1-[3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one

Application

Veliparib is a potent PARP-1/-2 inhibitor shown to potentiate DNA damaging agents

CAS Number

912444-00-9

Purity

≥99.0%

Molecular Weight

244.29

Molecular Formula

C13H16N4O

SMILES

NC(C1C=CC=C2N=C([C@]3(CCCN3)C)NC=12)=O

Target & IC50

PARP-1: IC50 = 5.2 nM (human)
EOL1: IC50 = 1.08 μM (human)
SNU-5: IC50 = 3.13 μM (human)
BV-173: IC50 = 5.45 μM (human)

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.0935 ml	20.4675 ml	40.9350 ml
5 mM	0.8187 ml	4.0935 ml	8.1870 ml
10 mM	0.4094 ml	2.0468 ml	4.0935 ml
50 mM	0.0819 ml	0.4094 ml	0.8187 ml

Solubility
DMSO: 29 mg/mL(118.7 mM)

Product Description

Veliparib, also named as AT-888, is poly (ADP-ribose) polymerase (PARP) inhibitor and has demonstrated excellent in vivo efficacy in a broad spectrum of preclinical tumor models in combination with a variety of cytotoxic agents. PARP is involved in DNA repair and elevated PARP levels can result in resistance to cytotoxic chemotherapy and radiation. So, PARP inhibitors hold promise as chemotherapy and radiation sensitizers. ABT-888 is also active on microsatellite instability (MSI) cell lines harboring mutations in both MRE11 and RAD50 genes compared to microsatellite stable (MSS) cell lines (wild-type for both genes).