Protein Inhibitors - Simvastatin (CAS: 79902-63-9)

Simvastatin (CAS: 79902-63-9)

Catalog #：EBC51095

Biological Activity

Synonyms

MK 733, MK-0733,MK733

Application

Simvastatin is a HMGCR inhibitor and anti-proliferative agent

CAS Number

79902-63-9

Purity

≥98.0%

Molecular Weight

418.57

Molecular Formula

C₂₅H₃₈O₅

SMILES

CCC(C)(C)C(O[C@H]1C[C@@H](C)C=C2C=C[C@H](C)[C@H](CC[C@@H]3C[C@@H](O)CC(O3)=O)[C@@]12[H])=O

Target & IC50

HES: IC50 = 6.5 nM
HMG-CoA reductase: IC50 = 3 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.3891 ml	11.9455 ml	23.8911 ml
5 mM	0.4778 ml	2.3891 ml	4.7782 ml
10 mM	0.2389 ml	1.1946 ml	2.3891 ml
50 mM	0.0478 ml	0.2389 ml	0.4778 ml

Solubility
DMSO: 20.9 mg/mL (50 mM) Ethanol: 20.9 mg/mL (50 mM)

Product Description

Simvastatin is an HMGCR (HMG-CoA reductase) inhibitor with anti-proliferative properties. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin-like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Mechanistic studies suggest that Simvastatin decreases CDK4 and CDK2 kinase activities and represses high glucose-induced Rho A (Rho GTPase)/p21 signaling in mesangial cells. Simvastatin also potentiates apoptosis in human myeloid leukemia cells via the suppression of TNF-induced NF-κB activation (IC50 ~ 13 µM).