| Biological Activity | |||||||||||||||||||||||||
| Synonyms | EED226, EED 226 | ||||||||||||||||||||||||
| Chemical Name | N-(Furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)[1,2,4]-triazolo[4,3-c]pyrimidin-5-amine | ||||||||||||||||||||||||
| Application | EED-226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor | ||||||||||||||||||||||||
| CAS Number | 2083627-02-3 | ||||||||||||||||||||||||
| Purity | ≥99.5% | ||||||||||||||||||||||||
| Molecular Weight | 369.4 | ||||||||||||||||||||||||
| Molecular Formula | C₁₇H₁₅N₅O₃S | ||||||||||||||||||||||||
| SMILES | CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4 | ||||||||||||||||||||||||
| Target & IC50 | EED;=82nM(Kd) PRC2;=114nM(Kd) |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 73 mg/mL (197.62 mM) |
| Product Description | |
EED-226 is a potent, selective, allosteric Polycomb repressive complex 2 (PRC2) inhibitor (IC₅₀ = 23.4 nM). EED-226 binds to the H3K27me3 binding pocket of EED (Embryonic Ectoderm Development) to allosterically inhibit PRC2. EED-226 induces robust and sustained tumor regression in EZH2MUT preclinical DLBCL model. |
