Other Biochemicals - Pleconarilis (CAS: 153168-05-9)

Pleconarilis (CAS: 153168-05-9)

Catalog #：EBC51033

Biological Activity

Synonyms

Win 63843, VP 63843, APO-P001, Picovir

Chemical Name

3-[3,5-Dimethyl-4-[3-(3-methyl-5-isoxazolyl)propoxy]phenyl]-5-(trifluoromethyl)-1,2,4-oxadiazole

Application

Pleconaril is a capsid inhibitor used previously to treat enterovirus infections

CAS Number

153168-05-9

Purity

≥99.85%

Molecular Weight

381.35

Molecular Formula

C₁₈H₁₈F₃N₃O₃

SMILES

FC(C1=NC(C2=CC(C)=C(OCCCC3=CC(C)=NO3)C(C)=C2)=NO1)(F)F

Target & IC50

Capsid: IC50 = 50 nM

Shipping

Room Temperature

Storage

Room Temperature

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.6223 ml	13.1113 ml	26.2226 ml
5 mM	0.5245 ml	2.6223 ml	5.2445 ml
10 mM	0.2622 ml	1.3111 ml	2.6223 ml
50 mM	0.0524 ml	0.2622 ml	0.5245 ml

Solubility
DMSO: 76 mg/mL (199.29 mM) Ethanol: 76 mg/mL (199.29 mM)

Product Description

Pleconaril is an antiviral drug potentially for the treatment of enterovirus infection and asthma. Pleconaril, administered either orally or intranasally, is active against viruses in the Picornaviridae family, including Enterovirus and Rhinovirus.It has shown useful activity against the dangerous strain enterovirus D68. Pleconaril binds to a hydrophobic pocket in the VP1 protein. Pleconaril has been shown in viral assembly to associate with viral particles.[9] Through noncovalent, hydrophobic interactions compounds can bind to the hydrophobic pocket. Amino acids in positions Tyr152 and Val191 are a part of the VP1 drug binding pocket.