Protein Inhibitors - 2-PMPA (CAS: 173039-10-6)

2-PMPA (CAS: 173039-10-6)

Catalog #：EBC51032

Biological Activity

Synonyms

NAALDase Inhibitor, PMPA

Chemical Name

2-(phosphonomethyl)pentanedioic acid

Application

2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII)

CAS Number

173039-10-6

Purity

≥98.0%

Molecular Weight

226.12

Molecular Formula

C₆H₁₁O₇P

SMILES

C(CC(=O)O)C(CP(=O)(O)O)C(=O)O

Target & IC50

GCPII: IC50= 300 pM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	4.4224 ml	22.1120 ml	44.2241 ml
5 mM	0.8845 ml	4.4224 ml	8.8448 ml
10 mM	0.4422 ml	2.2112 ml	4.4224 ml
50 mM	0.0884 ml	0.4422 ml	0.8845 ml

Solubility
H2O: 28 mg/mL (123.83 mM)

Product Description

2-PMPA is a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII) with an IC50 of 300 pM. InVitro: 2-PMPA is a potent and selective inhibitor of GCPII, an enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. 2-PMPA demonstrates robust efficacy in numerous animal models of neurological disease. 2-PMPA is a highly polar compound with multiple negative charges causing significant challenges for analysis in biological matrices. 2-PMPA reduces ketamine-induced decrease of cell viability and increase of LDH levels in the mixed cultures but not in the neuronal cultures.