Protein Inhibitors - FK-506 (CAS: 104987-11-3)

FK-506 (CAS: 104987-11-3)

Catalog #：EBC51030

Biological Activity

Synonyms

Tacrolimus, FR900506, Fujimycin

Application

FK-506 is an agent that binds to the immunophilin FKBP2 and inhibits calcineurin

CAS Number

104987-11-3

Purity

≥99.0%

Molecular Weight

804.02

Molecular Formula

C₄₄H₆₉NO₁₂

SMILES

C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC

Target & IC50

FKBP12: IC50 = 3 nM
IL-1, IL-2 : IC50 = 1 nM
IL-3, IL-4, IL-6: IC50 = 35 nM
GM-CSF, TNFα: IC50 = 10 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.2438 ml	6.2188 ml	12.4375 ml
5 mM	0.2488 ml	1.2438 ml	2.4875 ml
10 mM	0.1244 ml	0.6219 ml	1.2438 ml
50 mM	0.0249 ml	0.1244 ml	0.2488 ml

Solubility
DMSO: 80.4 mg/mL (100 mM) Ethanol: 80.4 mg/mL (100 mM)

Product Description

Tacrolimus, also known as FK-506, is a macrolide isolated from the fungus Streptomyces tsukubaensis. Tacrolimus binds to the FKBP-12 protein and Forms a complex with calcium-dependent proteins, thereby inhibiting calcineurin phosphatase activity and resulting in decreased cytokine production. This agent exhibits potent immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation. Tacrolimus possesses similar immunosuppressive properties to cyclosporine, but is more potent. Check For active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). For the detailed information about the solubility of FK-506 (Tacrolimus) in water, the solubility of FK-506 (Tacrolimus) in DMSO, the solubility of FK-506 (Tacrolimus) in PBS buffer, the animal experiment（test） of FK-506 (Tacrolimus),the in vivo,in vitro and clinical trial test of FK-506 (Tacrolimus),the cell experiment（test） of FK-506 (Tacrolimus),the IC50, EC50 and Affinity of FK-506 (Tacrolimus), please contact DC Chemicals.