Other Biochemicals - Avitinib maleate (CAS: 1557268-88-8)

Avitinib maleate (CAS: 1557268-88-8)

Catalog #：EBC51029

Biological Activity

Synonyms

AC0010MA， AC-0010MA， AC 0010MA， AC0010， AC-0010， AC 0010

Chemical Name

N-[3-[[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]prop-2-enamide

Application

Avitinib maleate is a pyrrolopyrimidine-based irreversible epidermal growth factor receptor (EGFR) inhibitor.

CAS Number

1557268-88-8

Purity

≥99.0%

Molecular Weight

603.61

Molecular Formula

C₃₀H₃₀FN₇O₆

SMILES

CN1CCN(CC1)C2=C(C=C(C=C2)NC3=NC4=C(C=CN4)C(=N3)OC5=CC=CC(=C5)NC(=O)C=C)F.C(=C\C(=O)O)\C(=O)O

Target & IC50

EGFR

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.6567 ml	8.2835 ml	16.5670 ml
5 mM	0.3313 ml	1.6567 ml	3.3134 ml
10 mM	0.1657 ml	0.8284 ml	1.6567 ml
50 mM	0.0331 ml	0.1657 ml	0.3313 ml

Solubility
DMSO: 300 mg/mL (497.02 mM)

Product Description

Avitinib, also known as AC0010 or AC0010MA, is an orally available, irreversible, epidermal growth factor receptor (EGFR) mutant-selective inhibitor, with potential antineoplastic activity. Upon oral administration, avitinib covalently binds to and inhibits the activity of mutant forms of EGFR, including the drug-resistant T790M EGFR mutant, which prevents signaling mediated by mutant forms of EGFR. This may both induce cell death and inhibit tumor growth in EGFR-mutated tumor cells. EGFR, a receptor tyrosine kinase that is mutated in a variety of cancers, plays a key role in tumor cell proliferation and tumor vascularization. As this agent is selective towards mutant forms of EGFR, its toxicity profile may be reduced when compared to non-selective EGFR inhibitors, which also inhibit wild-type EGFR.