Other Biochemicals - Ibiglustat (CAS: 1401090-53-6)

Ibiglustat (CAS: 1401090-53-6)

Catalog #：EBC51028

Biological Activity

Synonyms

GZ402671, SAR402671, Venglustat, GENZ-682452

Chemical Name

(3S)-1-azabicyclo[2.2.2]octan-3-yl N-{2-[2-(4-fluorophenyl)- 1,3-thiazol-4-yl]propan-2-yl}carbamate

Application

Ibiglustat is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor.

CAS Number

1401090-53-6

Purity

≥98.00%

Molecular Weight

389.49

Molecular Formula

C20H24FN3O2S

SMILES

O=C(O[C@@H]1CN2CCC1CC2)NC(C)(C3=CSC(C4=CC=C(F)C=C4)=N3)C

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.5675 ml	12.8373 ml	25.6746 ml
5 mM	0.5135 ml	2.5675 ml	5.1349 ml
10 mM	0.2568 ml	1.2837 ml	2.5675 ml
50 mM	0.0514 ml	0.2567 ml	0.5135 ml

Solubility
DMSO: 100 mM（19.49mg/ml）

Product Description

Ibiglustat, also known as GZ402671, GZ-452; Genz-682452 and SAR402671, is a potent and selective Glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor. Ibiglustat blocks the formation of glucosylceramide (GL-1), a key intermediate in the synthesis of GL-3. Ibiglustat is potentially useful for treating Fabry disease. Fabry disease is a rare lysosomal storage disorder, which results in abnormal tissue deposits of a particular fatty substance called globotriaosylceramide (GL-3 or Gb3) throughout the body.