Protein Inhibitors - RSV604 (CAS: 676128-63-5)

RSV604 (CAS: 676128-63-5)

Catalog #：EBC51027

Biological Activity

Synonyms

RSV-604，RSV 604

Application

RSV604 is an inhibitor of respiratory syncytial virus (RSV) that binds to RSV nucleoprotein (Kd = 1.31 μM)

CAS Number

676128-63-5

Purity

≥98.0%

Molecular Weight

388.39

Molecular Formula

C₂₂H₁₇FN₄O₂

SMILES

C1=CC=C(C=C1)C2=N[C@@H](C(=O)NC3=CC=CC=C32)NC(=O)NC4=CC=CC=C4F

Target & IC50

RSV:EC50 = 0.86 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.5747 ml	12.8737 ml	25.7473 ml
5 mM	0.5149 ml	2.5747 ml	5.1495 ml
10 mM	0.2575 ml	1.2874 ml	2.5747 ml
50 mM	0.0515 ml	0.2575 ml	0.5149 ml

Solubility
DMSO: 195 mg/mL (502.07 mM) Ethanol: 9 mg/mL (23.17 mM)

Product Description

RSV604 is a novel inhibitor of respiratory syncytial virus replication(EC50=0.86 uM); a putative RSV nucleoprotein(N) inhibitor in phase 2 clinical trials.IC50 value: 0.86 uM(EC50) It proved to be equipotent against all clinical isolates tested of both the A and B subtypes of the virus. The compound has a low rate of in vitro resistance development. Sequencing revealed that the resistant virus had mutations within the nucleocapsid protein. This is a novel mechanism of action for anti-RSV compounds. In a three-dimensional human airway epithelial cell model, RSV604 was able to pass from the basolateral side of the epithelium effectively to inhibit virus replication after mucosal inoculation. RSV604, which is currently in phase II clinical trials, represents the first in a new class of RSV inhibitors and may have significant potential for the effective treatment of RSV disease.