Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | Salermide | ||||||||||||||||||||||||
| Chemical Name | N-[3-[[(2-hydroxy-1-naphthalenyl)methylene]amino]phenyl]-a-methyl-benzeneacetamide | ||||||||||||||||||||||||
| Application | Salermide is an inhibitor of SIRT1, SIRT2, and HDAC | ||||||||||||||||||||||||
| CAS Number | 1105698-15-4 | ||||||||||||||||||||||||
| Purity | ≥99.0% | ||||||||||||||||||||||||
| Molecular Weight | 394.47 | ||||||||||||||||||||||||
| Molecular Formula | C26H22N2O2 | ||||||||||||||||||||||||
| SMILES | CC(C1=CC=CC=C1)C(=O)NC2=CC=CC(=C2)NC=C3C(=O)C=CC4=CC=CC=C43 | ||||||||||||||||||||||||
| Target & IC50 | SIRT2: IC50 = 25 μM (human) SIRT1: IC50 = 40.3 μM (human) |
||||||||||||||||||||||||
| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
|
|||||||||||||||||||||||||
| Solubility | |
| DMSO: 78 mg/mL (197.73 mM) Ethanol (warmed with 50oC water bath) 8 mg/mL (20.28 mM) |
| Product Description | |
Salermide is a reverse amide with strong inhibitory effects on SIRT1 (Sirtuin 1) and SIRT2 (Sirtuin 2). SIRT1/2 both belong to the family of NAD+-dependent class III histone deacetylases and are shown to target protein 53, a cell cycle regulator. Salermide is shown to induce acetylation of p53 and cause cell apoptosis. Salermide also inhibits members of HDAC3 (class III HDACs) |
