Protein Inhibitors - YM 155 (CAS: 781661-94-7)

YM 155 (CAS: 781661-94-7)

Catalog #：EBC51023

Biological Activity

Synonyms

Sepantronium bromide, YM-155, YM155

Chemical Name

1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide

Application

YM 155 is an inhibitor of survivin expression and apoptosis inducer

CAS Number

781661-94-7

Purity

≥99.0%

Molecular Weight

443.26

Molecular Formula

C₂₀H₁₉BrN₄O₃

SMILES

CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]

Target & IC50

Survivin: IC50 = 0.54nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.2559 ml	11.2793 ml	22.5586 ml
5 mM	0.4512 ml	2.2559 ml	4.5117 ml
10 mM	0.2256 ml	1.1279 ml	2.2559 ml
50 mM	0.0451 ml	0.2256 ml	0.4512 ml

Solubility
DMSO: 55 mg/mL (124.07 mM) Ethanol: 6 mg/mL (13.53 mM) Water: 89 mg/mL (200.77 mM)

Product Description

YM155, is a novel small-molecule suppressant of surviving, the smallest member of inhibitor of apoptosis (IAP) gene family. It exhibits a potent suppressive activity against survivin but has little effect on expression levels of other IAP family members or B-cell lymphoma 2 (BCL-2) related proteins. YM155 also suppresses proliferation in a broad range of human cancer cell lines, induces tumor regression in non-small cell lung cancer (NSCLC), melanoma, bladder, aggressive non-Hodgkin lymphoma, and breast cancer xenograft models, reduces spontaneous metastases, and significantly prolongs the survival of animal harboring established metastatic tumors derived from a human triple-negative breast cancer (TNBC) cell lines.