Protein Inhibitors - Trichostatin A (CAS: 58880-19-6)

Trichostatin A (CAS: 58880-19-6)

Catalog #：EBC51120

Biological Activity

Synonyms

TSA

Chemical Name

(2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide

Application

Trichostatin A is a potent and non-competitive reversible inhibitor of HDAC

CAS Number

58880-19-6

Purity

≥99.0%

Molecular Weight

302.37

Molecular Formula

C₁₇H₂₂N₂O₃

SMILES

CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C

Target & IC50

HDAC1 : IC50 = 70 nM; IL-2 gene expression : IC50 = 73 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.3072 ml	16.5360 ml	33.0721 ml
5 mM	0.6614 ml	3.3072 ml	6.6144 ml
10 mM	0.3307 ml	1.6536 ml	3.3072 ml
50 mM	0.0661 ml	0.3307 ml	0.6614 ml

Solubility
DMSO: 15.1 mg/mL (50 mM) Ethanol: 3 mg/mL (10 mM)

Product Description

Trichostatin A (TSA) is a potent and non-competitive reversible inhibitor of HDAC (histone deacetylase) with a Ki of 3.4 nM. In HeLa cells, Trichostatin A blocked cell cycle progression at G1 and induced a 12-fold increase in intracellular levels of gelsolin.Trichostatin A is a useful tool for induction of hyperacetylation of cellular histones and for further elucidation of their role in gene expression. Trichostatin A is also known as TSA, and [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide.