Protein Inhibitors - Pifithrin-α (CAS: 63208-82-2)

Pifithrin-α (CAS: 63208-82-2)

Catalog #：EBC51816

Biological Activity

Synonyms

PFT-α, PFTα hydrobromide, Pifithrin hydrobromide, Pifithrin-α

Chemical Name

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1- p-tolylethanone

Application

Pifithrin-α is an inhibitor of p53

CAS Number

63208-82-2

Purity

≥98.0%

Molecular Weight

367.30

Molecular Formula

C₁₆H₁₉BrN₂OS

SMILES

CC1=CC=C(C=C1)C(=O)CN2C3=C(CCCC3)SC2=N.Br

Target & IC50

P53

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.7226 ml	13.6129 ml	27.2257 ml
5 mM	0.5445 ml	2.7226 ml	5.4451 ml
10 mM	0.2723 ml	1.3613 ml	2.7226 ml
50 mM	0.0545 ml	0.2723 ml	0.5445 ml

Solubility
DMSO: 3.673 mg/mL (10 mM)

Product Description

Pifithrin-α is firstly found to block the activation of p53-responsive lacZ in ConA cells and reduce activation of endogenous cellular p53-responsive genes. In MEF cells transformed with E1a+ras, 10μM Pifithrin-α can inhibit the apoptosis of the cells and this anti-apoptotic activity is p53-dependent. Pifithrin-α also inhibits the growth arrest of human diploid fibroblasts induced by DNA damage but has no effect on p53-deficient fibroblasts. In addition, Pifithrin-α induces G2-arrest of cells after gamma irradiation.