Protein Inhibitors - A 83-01 (CAS: 909910-43-6)

A 83-01 (CAS: 909910-43-6)

Catalog #：EBC51012

Biological Activity

Synonyms

ALK5 Inhibitor IV

Chemical Name

3-(6-Methylpyridin-2-yl)-N-phenyl-4-quinolin-4-ylpyrazole-1-carbothioamide

Application

A 83-01 is a small-molecule inhibitor of activin receptorlike kinase (ALK)-5

CAS Number

909910-43-6

Purity

≥98.0%

Molecular Weight

421.52

Molecular Formula

C₂₅H₁₉N₅S

SMILES

CC1=CC=CC(=N1)C2=NN(C=C2C3=CC=NC4=CC=CC=C34)C(=S)NC5=CC=CC=C5

Target & IC50

ALK5 kinase: IC50 = 12 nM
ALK4: IC50 = 45 nM
ALK7: IC50 = 7.5 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.3724 ml	11.8618 ml	23.7237 ml
5 mM	0.4745 ml	2.3724 ml	4.7447 ml
10 mM	0.2372 ml	1.1862 ml	2.3724 ml
50 mM	0.0474 ml	0.2372 ml	0.4745 ml

Solubility
DMSO: 10mg/mL (23.72 mM)

Product Description

A 83-01 is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). A 83-01 blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. A 83-01 lonly weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. A 83-01 is more potent than SB 431542. Fibroblasts can be reprogrammed by A 83-01 into alternative lineages.