Protein Inhibitors - 17-AAG (CAS: 75747-14-7)

17-AAG (CAS: 75747-14-7)

Catalog #：EBC51010

Biological Activity

Synonyms

Tanespimycin

Chemical Name

17-Demethoxy-17-(2-propenylamino)-geldanamycin

Application

17-AAG is a potent heat shot protein 90 Hsp90) inhibitor for BT474 tumor cells, derived from geldanamycin.

CAS Number

75747-14-7

Purity

≥99.0%

Molecular Weight

585.69

Molecular Formula

C₃₁H₄₃N₃O₈

SMILES

O=C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@H](/C(C)=C/[C@@H]([C@H]([C@H](C[C@@H](C1)C)OC)O)C)OC(N)=O)=O)=CC2=O)C1=C2NCC=C

Target & IC50

Hsp90: = 5 μM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.7074 ml	8.5369 ml	17.0739 ml
5 mM	0.3415 ml	1.7074 ml	3.4148 ml
10 mM	0.1707 ml	0.8537 ml	1.7074 ml
50 mM	0.0341 ml	0.1707 ml	0.3415 ml

Solubility
DMSO: 58.0 mg/mL (100 mM)

Product Description

17-AAG is a less toxic and more stable analog of geldanamycin. 17-AAG is an Hsp90 inhibitor that displays a 100-fold higher affinity for Hsp90 derived from tumor cells compared to Hsp90 from normal cells. 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of anti tumor agents such as taxol2, cisplatin3, and UCN-014. 17-AAG causes the inactivation, destabilization and eventual degradation of HIF-1α5. In the prostate, 17-AAG can inhibit the growth of cancer cell lines.