Protein Inhibitors - RepSox (CAS: 446859-33-2)

RepSox (CAS: 446859-33-2)

Catalog #：EBC51009

Biological Activity

Synonyms

Ladakamycin, NSC 102816, Vidaza

Chemical Name

2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine

Application

RepSox is an ATP-competitive inhibitor of TGF-β RI kinase

CAS Number

446859-33-2

Purity

≥98.0%

Molecular Weight

287.32

Molecular Formula

C₁₇H₁₃N₅

SMILES

CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3)=CC=C1

Target & IC50

Autophosphorylation of TGF-β RI kinase: IC50 = 4 nM
ellular assay of TGF β RI kinase: IC50 = 18 nM

Shipping

Gel Pack

Storage

Store at -20°C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	3.4804 ml	17.4022 ml	34.8044 ml
5 mM	0.6961 ml	3.4804 ml	6.9609 ml
10 mM	0.3480 ml	1.7402 ml	3.4804 ml
50 mM	0.0696 ml	0.3480 ml	0.6961 ml

Solubility
DMSO: 53 mg/mL (184.5 mM)

Product Description

RepSox is a cell permeable, potent, selective and ATP-competitive inhibitor of TGF-β RI kinase (IC50=23nM, 4nM and 18nM for binding, auto-phosphorylation and cellular assay in HepG2 cells of TGF-β RI kinase, respectively). TGF β RI (ALK5) Inhibitor II affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16μM), minimally. ALK5 Inhibitor II has also been used as a basal media component for culturing human Pluripotent stem cells.