Protein Inhibitors - KU-55933 (CAS: 587871-26-9)

KU-55933 (CAS: 587871-26-9)

Catalog #：EBC51008

Biological Activity

Synonyms

ATM Kinase Inhibitor

Chemical Name

2-(4-Morpholinyl)-6-(1-thianthrenyl)-4H-pyran-4-one

Application

ATM Kinase Inhibitor is a cell-permeable, potent, selective and ATP-competitive ATM inhibitor

CAS Number

587871-26-9

Purity

≥99.0%

Molecular Weight

395.49

Molecular Formula

C₂₁H₁₇NO₃S₂

SMILES

C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4

Target & IC50

Atm: IC50 = 13 nM
mTOR: IC50 = 9.3 μM
PI3K: IC50 = 16.6 μM

Shipping

Gel Pack

Storage

Store at -20° C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.5285 ml	12.6425 ml	25.2851 ml
5 mM	0.5057 ml	2.5285 ml	5.0570 ml
10 mM	0.2529 ml	1.2643 ml	2.5285 ml
50 mM	0.0506 ml	0.2529 ml	0.5057 ml

Solubility
DMSO: 39.6 mg/mL (100 mM) Ethanol: 19.8 mg/mL (50 mM)

Product Description

ATM Kinase Inhibitor (KU 55933) is a cell-permeable, potent, selective and ATP-competitive inhibitor of ATM (Ataxia telangiectasia mutated), a serine/threonine protein kinase, that exhibits an IC50 of 13 nmol/L and a Ki of 2.2 nmol/L. ATM is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells and signals to cell cycle and DNA repair components by phosphorylating downstream targets such as p53, CHK2, NALP2 (NBS1), and BRCA1.