Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | (S)-(-)-Blebbistatin, (S)-(-)-Blebbistatin | ||||||||||||||||||||||||
| Chemical Name | 1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2.3-b]-7-methylquinolin-4-one | ||||||||||||||||||||||||
| Application | -(−)-Blebbistatin is an inhibitor of myosin II | ||||||||||||||||||||||||
| CAS Number | 856925-71-8 | ||||||||||||||||||||||||
| Purity | ≥99% | ||||||||||||||||||||||||
| Molecular Weight | 292.33 | ||||||||||||||||||||||||
| Molecular Formula | C₁₈H₁₆N₂O₂ | ||||||||||||||||||||||||
| SMILES | CC1=CC=C(N=C(N(C2=CC=CC=C2)CC3)[C@]3(O)C4=O)C4=C1 | ||||||||||||||||||||||||
| Target & IC50 | myosin II ATPase activity: IC50 = 5 μM ATPase: IC50 = 2 μM smooth muscle myosin: IC50 = 80 μM |
||||||||||||||||||||||||
| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20° C | ||||||||||||||||||||||||
|
|||||||||||||||||||||||||
| Solubility | |
| DMSO: 29.2 mg/mL (100 mM） |
| Product Description | |
(S)-(−)-Blebbistatin is a selective inhibitor of myosin II (MYH2). It also inhibits contraction of the cleavage furrow without disrupting of mitosis or the contractile ring assembly. (S)-(−)-Blebbistatin exhibits rapid and reversible blocking of cell blebbing, as well as disruption of directed cell migration and of cytokinesis in vertebrate cells. |
