Protein Inhibitors - PU-WS13 (CAS: 1454619-14-7)

PU-WS13 (CAS: 1454619-14-7)

Catalog #：EBC51017

Biological Activity

Synonyms

Grp94 inhibitor

Chemical Name

8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine

Application

Pu-ws13 is a selective GRP94 inhibitor

CAS Number

1454619-14-7

Purity

≥99.0%

Molecular Weight

411.35

Molecular Formula

C₁₇H₂₀Cl₂N₆S

SMILES

CC(NCCCN1C(SC2=CC(Cl)=CC(Cl)=C2)=NC3=C(N)N=CN=C13)C

Target & IC50

GRP94: EC50 = 0.22 μM
HSP90α: EC50 = 27.3 μM
HSP90β: EC50 = 41.8 μM

Shipping

Gel Pack

Storage

Store at -20° C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	2.4310 ml	12.1551 ml	24.3102 ml
5 mM	0.4862 ml	2.4310 ml	4.8620 ml
10 mM	0.2431 ml	1.2155 ml	2.4310 ml
50 mM	0.0486 ml	0.2431 ml	0.4862 ml

Solubility
DMSO : 40 mg/mL (97.24 mM)

Product Description

PU-WS13 is a Grp94 inhibitor, with an EC50 of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC50s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells