Protein Inhibitors - Rapamycin (CAS: 53123-88-9)

Rapamycin (CAS: 53123-88-9)

Catalog #：EBC51016

Biological Activity

Synonyms

AY 22989, Sirolimus, NSC-2260804

Application

Rapamycin is a potent and specific mTOR inhibitor with an IC50 of 0.1 nM in HEK293 cells

CAS Number

53123-88-9

Purity

≥98.0%

Molecular Weight

914.17

Molecular Formula

C₅₁H₇₉NO₁₃

SMILES

O=C([C@@]1(O)[C@@H](CC[C@@H](C[C@@H](/C(C)=C/C=C/C=C/[C@H](C[C@@H](C)C([C@@H]([C@@H](/C(C)=C/[C@H]2C)O)OC)=O)C)OC)O1)C)C(N3CCCC[C@H]3C(O[C@@H](CC2=O)[C@@H](C[C@H]4C[C@H]([C@H](O)CC4)OC)C)=O)=O

Target & IC50

mTOR: IC50 = 0.1 nM (in HEK293 cells)

Shipping

Gel Pack

Storage

Store at -20° C

Preparing Stock Solutions

Molecular Structure

ConcentrationSolventMass	1 mg	5 mg	10 mg
1 mM	1.0939 ml	5.4694 ml	10.9388 ml
5 mM	0.2188 ml	1.0939 ml	2.1878 ml
10 mM	0.1094 ml	0.5469 ml	1.0939 ml
50 mM	0.0219 ml	0.1094 ml	0.2188 ml

Solubility
DMSO: 100 mg/mL (109.39 mM) Ethanol: 100 mg/mL (109.39 mM)

Product Description

Rapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities. The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. Rapamycin also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due to the inhibition of FRAP autophosphorylation or protein kinase activity. Rapamycin also exhibits Angiogenesis inhibition, possibly through the inhibition of the Akt pathway. Rapamycin is an inhibitor of mTOR. Rapamycin is also known as Rapamune, 23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine, AY 22989, and mTOR Inhibitor I.