Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | SB-202190, SB202190, FHPI, 4-[4-(4-Fluorphenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol | ||||||||||||||||||||||||
| Chemical Name | 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole | ||||||||||||||||||||||||
| Application | SB 202190 is an inhibitor of the isoforms p38α and p38β | ||||||||||||||||||||||||
| CAS Number | 152121-30-7 | ||||||||||||||||||||||||
| Purity | ≥98% | ||||||||||||||||||||||||
| Molecular Weight | 331.34 | ||||||||||||||||||||||||
| Molecular Formula | C₂₀H₁₄FN₃O | ||||||||||||||||||||||||
| SMILES | FC1=CC=C(C2=C(C3=CC=NC=C3)NC(C4=CC=C(O)C=C4)=N2)C=C1 | ||||||||||||||||||||||||
| Target & IC50 | p38α: IC50 = 14.3 nM (human) p38 MAP kinase: IC50 = 30 nM p38 β: IC50 = 100 nM Toxoplasma gondii: IC50 = 1 μM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20° C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 33.1 mg/mL (100 mM) PS: < 1 mg/ml refers to the product slightly soluble or insoluble |
| Product Description | |
SB 202190 is a selective and potent p38 MAP kinases inhibitor, binding to its ATP pocket. It has negligible inhibiting properties on other MAP kinases such as ERKs and JNKs. SB 202190 is reported to be used to induce cardiomyocyte differentiation from human embryonic stem cells and increase neural stem cell self-renewal. |
