Photo：010-62890160
| Biological Activity | |||||||||||||||||||||||||
| Synonyms | MG132, MG 132, Z-LLL-al, Z-Leu-Leu-Leu-CHO | ||||||||||||||||||||||||
| Chemical Name | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide | ||||||||||||||||||||||||
| Application | MG-132 is a potent cell-permeable 20S proteasome inhibitor | ||||||||||||||||||||||||
| CAS Number | 133407-82-6 | ||||||||||||||||||||||||
| Purity | ≥98.0% | ||||||||||||||||||||||||
| Molecular Weight | 475.62 | ||||||||||||||||||||||||
| Molecular Formula | C₂₆H₄₁N₃O₅ | ||||||||||||||||||||||||
| SMILES | O=C(OCC1=CC=CC=C1)N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C([H])=O)CC(C)C)=O)=O)CC(C)C | ||||||||||||||||||||||||
| Target & IC50 | NF-κB: IC50 = 3 μM Suc-LLVY-AMC: IC50 = 0.85 μM Z-LLL-AMC: IC50 = 0.1 μM IκBα: IC50 = 3 μM |
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| Shipping | Gel Pack | ||||||||||||||||||||||||
| Storage | Store at -20°C | ||||||||||||||||||||||||
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| Solubility | |
| DMSO: 93 mg/mL (139.1 mM) |
| Product Description | |
MG-132 (Z-Leu-Leu-Leu-al) is a potent proteasome and calpain inhibitor with IC50s of 100 nM and 1.2 μM, respectively. MG-132 effectively blocks the proteolytic activity of the 26S proteasome complex. MG-132, a peptide aldehyde, also is an autophagy activato MG-132 also induces apoptosis |
